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吕雷阳 Leiyang Lv
中国人民大学
lvleiyang2008@163.com

个人情况:

男,1989.6生,山东省,中共党员

Emaillvleiyang2008@163.com

学习、工作经历:

2020/9—至今      副教授  中国人民大学  威斯尼斯人app下载安装

2019/92020/8    博士后    McGill University                              导师 李朝军 教授

2017/92019/8    博士后 兰州大学/McGill University                导师 李朝军 教授

2012/92017/7    博士      中国人民大学                                   导师 李志平 教授

2008/92012/7    学士      青岛科技大学

研究方向:

绿色合成化学

       有机氟化学

仿生药物合成

合成生物学

获得奖项及荣誉:

中国人民大学“杰出学者”(青年B岗)

博士生国家奖学金 (2014年, 2015)

光华奖学金 (2016)

中国人民大学第十届“学术新星”奖 (2016)

第十四届全国均相催化“优秀学生报告奖”(2015)

    代表性论文:

[1] Luo, Y.; Xu, B.; Lv, L.*; Li, Z.* Copper-Catalyzed Three-Component Germyl Peroxidation of Alkenes. Org. Lett. 2022, doi: 10.1021/acs.orglett.2c00698.

[2] Wang, L.; Lv, L.*; Li, Z.* Concomitant functionalization of two different ketones by merging Brønsted acid catalysis and radical relay coupling. Org. Chem. Front. 2022, 9, 1561-1566.

[3] Gao, G.; Mao, K.; Lv, L.*; Li, Z.* Three-Component Coupling of α-Trifluoromethyl Carbonyls, Azides and Amines for the Regioselective Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles. Adv. Synth. Catal. 2022, doi: 10.1002/adsc.202200094.

[4] Ma, Y.; Lv, L.*; Li, Z.* β-Perfluoroalkyl Peroxides as Fluorinated C3-Building Blocks for the Construction of Benzo[4,5]imidazo[1,2-a]pyridines. J. Org. Chem. 2022, 87, 1564-1573.

[5] Lv, L.; Gao, G.; Luo, Y.; Mao, K.; Li, Z.* Three-Component Reactions of alpha-CF3 Carbonyls, NaN3, and Amines for the Synthesis of NH-1,2,3-Triazoles. J. Org. Chem. 2021, 86, 17197-17212.

[6] Lv, L.*; Qian, H.; Ma, Y.; Huang, S.; Yan, X.; Li, Z.* Ligand-controlled regioselective and chemodivergent defluorinative functionalization of gem-difluorocyclopropanes with simple ketones. Chem. Sci. 2021, 12, 15511-15518.

[7] Lou, C.; Wang, X.; Lv, L.*; Li, Z.* Iron-Catalyzed Ring-Opening Reactions of Cyclopropanols with Alkenes and TBHP: Synthesis of 5-Oxo Peroxides. Org. Lett. 2021, 23, 7608-7612.

[8] Luo, Y.; Tian, T.; Nishihara, Y.; Lv, L.*; Li, Z.* Iron-catalysed radical cyclization to synthesize germanium-substituted indolo[2,1-a]isoquinolin-6(5H)-ones and indolin-2-ones. Chem. Commun. 2021, 57, 9276-9279.

[9] Wang, X.; Lou, C.; Lv, L.*; Li, Z.* Annulative pi-Extension (APEX) of Indoles to Pyrido[1,2-a]indoles Using 4-Oxo Peroxides as C4 Units. Org. Lett. 2021, 23, 5978-5982.

[10] Wang, L.; Ma, Y.; Jiang, Y.; Lv, L.*; Li, Z.* A Mn-catalyzed remote C(sp(3))-H bond peroxidation triggered by radical trifluoromethylation of unactivated alkenes. Chem. Commun. 2021, 57, 7846-7849.

[11] Lv, L.*; Li, C.-J.* Pd-Catalyzed Defluorinative Alkylation of gem-Difluorocyclopropanes: Switching Regioselectivity via Simple Hydrazones. Angew. Chem. Int. Ed. 2021, 60, 13098-13104.

[12] Lv, L.*; Li, C.-J.* Ruthenium Catalyzed β-Selective Alkylation of Vinylpyridines with Aldehydes/Ketones via N2H4 Mediated Deoxygenative Couplings. Chem. Sci. 2021, 12, 2870-2875.

[13] Ma, Y.; Chen, Y.; Lv, L.*; Li, Z.* Regioselective Synthesis of Emission Color‐Tunable Pyrazolo[1,5‐a]pyrimidines with β,β‐Difluoro Peroxides as 1,3‐Bis‐Electrophiles. Adv. Synth. Catal. 2021, 363, 3233–3239.

[14] Li, L.; Huang, S.; Mao, K.; Lv, L.*; Li, Z.* Synthesis of Isoxazoles via Cyclization of β-Fluoro Enones with Sodium Azide. Tetrahedron. Lett. 2021, 71, 153052-153056.

[15] Tian, T.; Wang, X.; Lv, L.*; Li, Z.* Iron-Catalyzed Acylation-Functionalization of Unactivated Alkenes with Aldehydes. Chem. Commun. 2020, 56, 14637-14640.

[16] Lv, L. ; Yu, L. ; Qiu, Z.; Li, C.-J. Switch in Selectivity for the Formal Hydroalkylation of 1,3-Dienes and Enynes with Simple Hydrazones. Angew. Chem. Int. Ed. 2020, 59, 6466-6472. (VIP paper, IF = 12.959)

[17] Yu, L. ; Lv, L. ; Qiu, Z.; Chen, Z.; Tan, Z.; Liang, Y.-F.; Li, C.-J. Pd-Catalyzed Formal Hydroalkylation of Aryl-Substituted Alkynes with Hydrazones. Angew. Chem. Int. Ed. 2020, 59, 14009-14013. (contributed equally) (Hot paper, IF = 12.959)

[18] Lv, L. ; Zhu, D. ; Li, C.-J. Direct Dehydrogenative Alkyl Heck-Couplings of Vinylarenes with Umpolung Aldehydes Catalyzed by Nickel. Nat. Commun. 2019, 10, 715. (IF = 12.121)

[19] Lv, L. ; Qiu, Z. ; Li, J.; Liu, M.; Li, C.-J. N2H4 as Traceless Mediator for Homo- and Cross- Aryl Coupling. Nat. Commun. 2018, 9, 4739.

[20] Lv, L.; Shen, B.; Li, Z. Total Synthesis of (+)-Clavilactones A, B, and Proposed D through Iron-Catalyzed Carbonylation–Peroxidation of Olefin. Angew. Chem. Int. Ed. 2014, 53, 4164-4167.

[21] Lv, L. ; Zhu, D. ; Tang, J.; Qiu, Z.; Li, C.-C.; Gao, J.; Li, C.-J. Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel. ACS Catal. 2018, 8, 4622-4627.

[22] Lv, L.; Zhu, D.; Qiu, Z.; Li, J.; Li, C.-J. Nickel-Catalyzed Regioselective Hydrobenzylation of 1,3-Dienes with Hydrazones. ACS Catal. 2019, 9, 9199-9205. (IF = 12.350)

[23] Zhu, D.; Lv, L.; Li, C.-C.; Ung, S.; Gao, J.; Li, C.-J. Umpolung of Carbonyls as Alkyl Organometallic Reagent Surrogates for Palladium Catalyzed Allylic Alkylation. Angew. Chem. Int. Ed. 2018, 57, 16520-16524. (contributed equally) (IF = 12.959)

[24] Zhou, Z.-Z.; Liu, M.; Lv, L.; Li, C.-J. Silver (I)-Catalyzed Widely Applicable Aerobic 1,2-Diol Oxidative Cleavage. Angew. Chem. Int. Ed. 2018, 57, 2616-2620. (contributed equally) (IF = 12.959)

[25] Lv, L.; Lu, S.; Guo, Q.; Shen, B.; Li, Z. Iron-Catalyzed Acylation-Oxygenation of Terminal Alkenes for the Synthesis of Dihydrofurans Bearing a Quaternary Carbon. J. Org. Chem. 2015, 80, 698-704.

[26] Lv, L.; Xi, H.; Bai, X.; Li, Z. Iron-Catalyzed Convergent Radical Cyclization of Aldehydes with Two Alkenes to 3,4-Dihydropyrans. Org. Lett. 2015, 17, 4324-4327.

[27] Lv, L.; Qi, L.; Guo, Q.; Shen, B.; Li, Z. Iron-Catalyzed Divergent Tandem Radical Annulation of Aldehydes with Olefins toward Indolines and Dihydropyrans. J. Org. Chem. 2015, 80, 12562-12571.

[28] Lv, L.; Li, Z. Iron-Catalyzed Radical [2+2+2] Annulation of Benzene-Linked 1,7-Enynes with Aldehydes: Fused Pyran Compounds. Org. Lett. 2016, 18, 2264-2267.

[29] Lv, L.; Bai, X.; Yan, X.; Li, Z. Iron-Catalyzed Decarbonylation Initiated [2+2+m] Annulation of Benzene-Linked 1,n-Enynes with Aliphatic Aldehydes. Org. Chem. Front. 2016, 3, 1509-1513.

[30] Lv, L.; Li, Z. Fe-Catalyzed Cross-Dehydrogenative Couplings. Top. Curr. Chem. (Z) 2016, 374, 38. (Invited review)

[31] Lv, L.; Li, Z. Iron-Catalyzed Oxidative Cyclization of 1,6-Enones with Aldehydes: Synthesis of Functionalized 3,4-Dihydro-2H-pyrans. Chin. J. Chem. 2017, 35, 303-306.

[32] Lv, L.; Li, Z. Cycloalkylation of C(sp3)-H Bond with Neighboring Carboxylic Acid as Traceless Activating Group. J. Org. Chem. 2017, 82, 2689-2702.

[33] Lv, L.; Snider, B. B.; Li, Z. Total Synthesis and Structure Revision of (±)-Clavilactone D Through Selective Cyclization of an α,β-Dicarbonyl Peroxide. J. Org. Chem. 2017, 82, 5487-5491.

[34] Lv, L.; Lu, S.; Chen, Y.; Li, Z. Diastereoselective Building up Polycyclic Tetrahydrofurans via Tandem Annulation of 1,n-Enynes with Aliphatic Acids. Org. Chem. Front. 2017, 4, 2147-2152.

[35] Lv, L.;* Li, Z. * FeCl3-Catalyzed Regio-Divergent Carbosulfenylation of Unactivated Alkenes: Construction of Medium-Sized Ring. J. Org. Chem. 2018, 83, 10985-10994.

[36] Zhu, D.; Lv, L.; Li, C.-J. Nickel-Catalyzed Cross-Coupling of Umpolung Carbonyls and Alkyl Halides. J. Org. Chem. 2019, 84, 6312-6322. (contributed equally).

[37] Zheng, X.; Lv, L.; Lu, S.; Wang, W.; Li, Z. Benzannulation of Indoles to Carbazoles and Its Applications for Synthesis of Carbazole Alkaloids. Org. Lett. 2014, 16, 5156-5159.

[38] Bai, X.; Lv, L.; Li, Z. Copper-Catalyzed Tandem Trifluoromethylation-Cyclization of Olefinic Carbonyls: Synthesis of Trifluoromethylated 2,3-Dihydrofurans and 3,4-Dihydropyrans. Org. Chem. Front. 2016, 3, 804-808.

[39] Tang, J.; Lv, L.; Dai, X.-J.; Li, C.-C.; Li, L.; Li, C.-J. Nickel-Catalyzed Cross-Coupling of Aldehydes with Aryl Halides via Hydrazone Intermediates. Chem. Commun. 2018, 54, 1750-1753.

[40] Li, J. ; Zhu, D. ; Lv, L.; Li, C.-J. Radical Difluoromethylthiolation of Aromatics Enabled by Visible Light. Chem. Sci. 2018, 9, 5781-5786.

[41] Liu, W. ; Liu, P. ; Lv, L.; Li, C.-J. Metal-Free and Redox-Neutral Conversion of Organotrifluoroborates into Radicals Enabled by Visible Light. Angew. Chem. Int. Ed. 2018, 57, 13499-13503.

[42] Qiu, Z.; Lv, L.; Li, J.; Li, C.-C.; Li, C.-J. Direct Conversion of Phenols into Primary Anilines with Hydrazine Catalyzed by Palladium. Chem. Sci. 2019, 10, 4775-4781.

[43] Li, C.-J.; Huang, J.; Dai, X.-J.; Wang, H.; Chen, N.; Wei, W.; Zeng, H.; Tang, J.; Li, C.; Zhu, D.; Lv, L. An Old Dog with New Tricks: Enjoin Wolff-Kishner Reduction for Alcohol Deoxygenation and C-C Bond Formations. Synlett, 2019, 30, 1508-1524.

[44] Li, C.-C.; Kan, J.; Qiu, Z.; Li, J.; Lv, L.; Li, C.-J. Synergistic Relay Reactions to Achieve Redox-Neutral α-Alkylation of Olefinic Alcohols with Ruthenium(II)-Catalysis. Angew. Chem. Int. Ed. 2020, 59, 4544-4549.

[45] Yao, J.; Chen, Z.; Yu, L.; Lv, L.; Cao, D.; Li, C.-J. Palladium-catalyzed Hydroalkylation of Methylenecyclopropanes with Simple Hydrazones. Chem. Sci. 2020, 11, 10759-10763 (IF = 9.556)

[46] Cao, D.; Chen, Z.; Lv, L.; Zeng, H.; Peng, Y.; Li, C.-J. Light-Driven Metal-Free Direct Deoxygenation of Alcohols under Mild Conditions. iScience, 2020, 23, 101419.

[47] Tian, T.; Wang, X.; Lv, L.; Li, Z. Iron-Catalyzed [2+2+2] Annulation of Aliphatic Bridged 1,n-Enynes with Aldehydes for the Synthesis of Fused Pyrans. E. J. Org. Chem. 2020, 4425-4428.

[48] Kan, J.; Chen, Z.; Qiu, Z.; Lv, L.; Li, C.; Li, C.-J. Umpolung carbonyls enable direct allylation and olefination of carbohydrates. Sci. Adv. 2022, 8, eabm6840.